FM-479
Cat. No.：YN340124
| 产品名称: | FM-479 |
| CAS No.: | 2226521-64-6 |
| Chemical Name: | |
| Synonyms: | BCP32593;FM 479;FM479;(E)-2-Cyano-3-[5-(3-cyclohexyl-10-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-penta |
| 分子量: | 442.51 |
| 分子式: | C₂₅H₂₆N₆O₂ |
| SMILES: | O=C(N(C)C)/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FM-479 为 FM-381 (HY-102046) 阴性对照 (negative control)，对 JAK3 或其他激酶无活性。FM-381 是一个有效的共价可逆抑制剂JAK3靶向独特的 Cys909。对于 JAK3, FM-381 具有IC50为 127 pM 的选择性，分别比 JAK1、JAK2 和 TYK2 有 410 倍、2700 倍和 3600 倍选择性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
