NVP-BSK805 dihydrochloride
Cat. No.：YN340160
CAS No. ：1942919-79-0
| 产品名称: | NVP-BSK805 dihydrochloride |
| CAS No.: | 1942919-79-0 |
| Chemical Name: | 4-(2,6-difluoro-4-(3-(1-(pip4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine, dihydrochloride |
| Synonyms: | 盐酸NVP-BSK805,NVP-BSK805 (dihydrochloride),BSK 805 |
| 分子量: | 563.47 |
| 分子式: | C₂₇H₃₀Cl₂F₂N₆O |
| SMILES: | FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-BSK805 dihydrochloride 是一种 ATP 竞争性的JAK2抑制剂，对 JAK2 JH1 (JAK 同源 1)，JAK1 JH1，JAK3 JH1，和 TYK2 JH1 的IC50值分别为 0.48 nM，31.63 nM，18.68 nM 和 10.76 nM。 |
| IC50和靶点: | [{name:"JAK2 JH1:0.48 nM (IC50)"},{name: "FL JAK2 V617F:0.56 nM (IC50)"},{name: "FL JAK2 wt:0.58 nM (IC50)"},{name: "TYK2 JH1:10.76 nM (IC50)"},{name: "JAK3 JH1:18.68 nM (IC50)"},{name: "JAK1 JH1:31.63 nM (IC50)"}] |
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Yamaoka, K., Saharinen, P., Pesu, M., et al.The Janus kinases (Jaks)Genome Biol.5(12),253(2004)
Baffert, F., Régnier, C.H., De Pover, A., et al.Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805Mol. Cancer Ther.9(7),1945-1955(2010)
Rubert, J., Qian, Z., Andraos, R., et al.Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survivalBMC Cancer11:24,(2011)
