CEP-33779
Cat. No.:YN340173
CAS No. :1257704-57-6
产品名称: | CEP-33779 |
CAS No.: | 1257704-57-6 |
Chemical Name: | N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine |
Synonyms: | CEP33779 |
分子量: | 462.57 |
分子式: | C₂₄H₂₆N₆O₂S |
SMILES: | O=S(C1=CC=C(C2=CC=CN3C2=NC(NC4=CC=CC(N5CCN(C)CC5)=C4)=N3)C=C1)(C)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | CEP-33779是一个新颖的,选择性,有口服活性的JAK2抑制剂,IC50值为1.8±0.6 nM。 |
IC50和靶点: | [{name:"JAK2:1.8 nM (IC50)"},{name: "JAK3:150 nM (IC50)"}] |
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Yamaoka, K., Saharinen, P., Pesu, M., et al.The Janus kinases (Jaks)Genome Biol.5(12),253(2004)
Lu, L.D., Stump, K.L., Wallace, N.H., et al.Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2J. Immunol.187(7),3840-3853(2011)
Stump, K.L., Lu, L.D., Dobrzanski, P., et al.A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritisArthritis Res. Ther.13(2),1-15(2011)
Seavey, M.M., Lu, L.D., Stump, K.L., et al.Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancerMol. Cancer Ther.11(4),984-993(2012)