PF-06409577
Cat. No.：YN420044
CAS No. ：1467057-23-3
规格
价格(RMB)
库存
| 产品名称: | PF-06409577 |
| CAS No.: | 1467057-23-3 |
| Chemical Name: | 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid |
| Synonyms: | PF 06409577 |
| 分子量: | 341.79 |
| 分子式: | C₁₉H₁₆ClNO₃ |
| SMILES: | O=C(C1=CNC2=C1C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-06409577是有效，选择性的AMPKα1β1γ1 亚型变构激活剂，EC50值为7 nM。 |
| IC50和靶点: | [{name:"AMPK α1β1γ1:7 nM (EC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Cameron, K.O., Kung, D.W., Kalgutkar, A.S., et al.Discovery and preclinical characterization of 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid (PF-06409577), a direct activator of adenosine monophosphate-activated protein kinase (AMPK), for the potential treatment of diabetic nephropathyJ. Med. Chem.59(17),8068-8081(2016)
