NVP-ADW742
Cat. No.：YN440068
CAS No. ：475488-23-4
规格
价格(RMB)
库存
| 产品名称: | NVP-ADW742 |
| CAS No.: | 475488-23-4 |
| Chemical Name: | 5-[3-(phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonyms: | ADW742; GSK 552602A; ADW |
| 分子量: | 453.58 |
| 分子式: | C₂₈H₃₁N₅O |
| SMILES: | NC1=C2C(N(C=C2C3=CC=CC(OCC4=CC=CC=C4)=C3)[C@H]5C[C@@H](C5)CN6CCCC6)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-ADW742 (ADW742) 是一种具有口服活性，选择性的IGF-1R酪氨酸激酶抑制剂，IC50为 0.17 μM。NVP-ADW742 抑制胰岛素受体 (InsR)，IC50为 2.8 μM。NVP-ADW742 在肿瘤细胞中诱导多效性抗增殖/促凋亡 (apoptosis)。 |
| IC50和靶点: | |
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Mitsiades, C.S., Mitsiades, N.S., McMullan, C.J., et al.Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumorsCancer Cell5(3),221-230(2004)
