PNU-74654
Cat. No.：YN450016
CAS No. ：113906-27-7
规格
价格(RMB)
库存
| 产品名称: | PNU-74654 |
| CAS No.: | 113906-27-7 |
| Chemical Name: | 2-phenoxy-benzoic acid, 2-[(5-methyl-2-furanyl)methylene]hydrazide |
| Synonyms: | PNU74654; PNU 74654 |
| 分子量: | 320.34 |
| 分子式: | C₁₉H₁₆N₂O₃ |
| SMILES: | O=C(N/N=C/C1=CC=C(C)O1)C2=CC=CC=C2OC3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PNU-74654是Wnt/β-catenin通路的的抑制剂，在NCI-H295 细胞中的IC50值为129.8 μM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Barker, N., and Clevers, H.Mining the Wnt pathway for cancer therapeuticsNat. Rev. Drug Discov.5(12),997-1014(2006)
Trosset, J.Y., Dalvit, C., Knapp, S., et al.Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screeningProteins64(1),60-67(2006)
Durand, J., Lampron, A., Mazzuco, T.L., et al.Characterization of differential gene expression in adrenocortical tumors harboring β-catenin (CTNNB1) mutationsJ. Clin. Endocrinol. Metab.96(7),E1206-E1211(2011)
