FH535
Cat. No.：YN450111
CAS No. ：108409-83-2
规格
价格(RMB)
库存
| 产品名称: | FH535 |
| CAS No.: | 108409-83-2 |
| Chemical Name: | 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-benzenesulfonamide |
| Synonyms: | N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide;FH535;2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide;FH-535;FH 535(FH-535);2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535;Tcf Inhibitor, FH535;β-Catenin;β- |
| 分子量: | 361.20 |
| 分子式: | C₁₃H₁₀Cl₂N₂O₄S |
| SMILES: | O=S(C1=CC(Cl)=CC=C1Cl)(NC2=CC=C([N+]([O-])=O)C=C2C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FH535 是Wnt/β-catenin和PPAR的抑制剂，具有抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Handeli, S., and Simon, J.A.A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activitiesMol. Cancer Ther.7(3),521-529(2008)
Faisy, C., Grassin-Delyle, S., Blouquit-Laye, S., et al.Wnt/ß-catenin signaling modulates human airway sensitization induced by ß2-adrenoceptor stimulationPLoS One9(10),(2014)
Su, H., Jin, X., Zhang, X., et al.FH535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line KYSE-150RJ. Transl. Med.13,104(2015)
Wu, M.Y., Liang, R.R., Chen, K., et al.FH535 inhibited metastasis and growth of pancreatic cancer cellsOnco Targets Ther.8,1651-1670(2015)
