JW74
Cat. No.：YN450129
CAS No. ：863405-60-1
规格
价格(RMB)
库存
| 产品名称: | JW74 |
| CAS No.: | 863405-60-1 |
| Chemical Name: | 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine |
| Synonyms: | |
| 分子量: | 456.52 |
| 分子式: | C₂₄H₂₀N₆O₂S |
| SMILES: | CC1=CC=C(C2=NOC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=C(OC)C=C5)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JW74 拮抗 LiCl 诱导的经典Wnt信号传导的激活，IC50为 420 nM。 |
| IC50和靶点: | |
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Stratford, E.W., Daffinrud, J., Munthe, E., et al.The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell linesCancer Med.3(1),36-46(2014)
Waaler, J., Machon, O., von Kries, J.P., et al.Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growthCancer Res.71(1),197-205(2011)
