CCT251545
Cat. No.：YN450062
CAS No. ：1661839-45-7
规格
价格(RMB)
库存
| 产品名称: | CCT251545 |
| CAS No.: | 1661839-45-7 |
| Chemical Name: | 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one |
| Synonyms: | CCT251545;CCT-251545 |
| 分子量: | 421.92 |
| 分子式: | C₂₃H₂₄ClN₅O |
| SMILES: | O=C1NCCC12CCN(C3=C(Cl)C=NC=C3C4=CC=C(C5=CN(C)N=C5)C=C4)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCT251545 是一种口服生物有效的WNT抑制剂, 在 7dF3 细胞中对 WNT 抑制作用的IC50值为 5 nM。CCT251545 是一种选择性化学探针，用于探索 CDK8 和 CDK19 在人类疾病中的作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mallinger, A., Crumpler, S., Pichowicz, M., et al.Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screenJ. Med. Chem.58(4),1717-1735(2015)
Dale, T., Clarke, P.A., Esdar, C., et al.A selective chemical probe for exploring the role of CDK8 and CDK19 in human diseaseNat. Chem. Biol.11(12),973-980(2015)
