iCRT 14
Cat. No.：YN450120
CAS No. ：677331-12-3
规格
价格(RMB)
库存
| 产品名称: | iCRT 14 |
| CAS No.: | 677331-12-3 |
| Chemical Name: | 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione |
| Synonyms: | iCRT-14;(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione;iCRT 14;5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione |
| 分子量: | 375.44 |
| 分子式: | C₂₁H₁₇N₃O₂S |
| SMILES: | O=C(S/1)N(C2=CC=CC=C2)C(C1=C\C3=C(C)N(C(C)=C3)C4=CN=CC=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | iCRT 14 是一种 β-连环蛋白应答转录（CRT）抑制剂，能够抑制 Wnt 信号通路，IC50值为 40.3 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gonsalves, F.C., Klein, K.O., Carson, B.B., et al.An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathwayProc. Natl. Acad. Sci. USA108(15),5954-5963(2011)
Huang, Z., Zhang, M., Burton, S.D., et al.Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactionsACS Chem Biol.9(1),193-201(2014)
Dandekar, S., Romanos-Sirakis, E., Pais, F., et al.Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukemiaBr. J. Haematol.167(1),87-99(2014)
Zhang, J.L., Liu, Y., Yang, H., et al.ATP-P2Y2-β-catenin axis promotes cell invasion in breast cancer cellsCancer Sci.108(7),1318-1327(2017)
