Tubulin inhibitor 6
Cat. No.：YN290274
CAS No. ：105925-39-1
| 产品名称: | Tubulin inhibitor 6 |
| CAS No.: | 105925-39-1 |
| Chemical Name: | (2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)-methanone |
| Synonyms: | iHAP1 |
| 分子量: | 367.85 |
| 分子式: | C₂₀H₁₄ClNO₂S |
| SMILES: | O=C(N1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13)C4=CC=C(OC)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tubulin inhibitor 6 (Compound 14b) 是一种微管蛋白 (tubulin) 抑制剂，也是多种肿瘤细胞系的有效抑制剂。Tubulin inhibitor 6 抑制微管蛋白聚合，IC50为 0.87 μM。Tubulin inhibitor 6 抑制 K562 细胞生长，IC50为 840 nM。 |
| IC50和靶点: | |
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Prinz, H., Chamasmani, B., Vogel, K., et al.N-benzoylated phenoxazines and phenothiazines: Synthesis, antiproliferative activity, and inhibition of tubulin polymerizationJ. Med. Chem.54(12),4247-4263(2011)
Morita, K., He, S., Nowak, R.P., et al.Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2Cell181(3),702-715.e720(2020)
Morita, K., He, S., Nowak, R.P., et al.Retraction Notice to: Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2Cell185(16),3058(2022)
Vit, G., Duro, J., Rajendraprasad, G., et al.Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061EMBO J.41(14),e110611(2022)
Tin, G., Mohamed, T., Gondora, N., et al.Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's diseaseMed. Chem. Comm.6,1930-1941(2015)
