Ombrabulin hydrochloride
Cat. No.：YN290427
CAS No. ：253426-24-3
| 产品名称: | Ombrabulin hydrochloride |
| CAS No.: | 253426-24-3 |
| Chemical Name: | 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-propanamide, monohydrochloride |
| Synonyms: | AVE8062 hydrochloride; AC7700 hydrochloride |
| 分子量: | 438.90 |
| 分子式: | C₂₁H₂₇ClN₂O₆ |
| SMILES: | O=C(NC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC)[C@@H](N)CO.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ombrabulin hydrochloride 是 CA-4 磷酸酯的衍生物，选择性破坏内皮细胞的微管蛋白细胞骨架，具有抗血管作用。 |
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Monk, K., Siles, R., Hadimani, M.B., et al.Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agentsBioorg. Med. Chem.14(9),3231-3244(2006)
Kim, T.J., Ravoori, M., Landen, C.N., et al.Antitumor and antivascular effects of AVE8062 in ovarian carcinomaCancer Res.67(19),9337-9345(2007)
