Cevipabulin
Cat. No.：YN290324
CAS No. ：849550-05-6
| 产品名称: | Cevipabulin |
| CAS No.: | 849550-05-6 |
| Chemical Name: | 5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine |
| Synonyms: | TTI-237 |
| 分子量: | 464.82 |
| 分子式: | C₁₈H₁₈ClF₅N₆O |
| SMILES: | C[C@@]([H])(C(F)(F)F)NC1=C(C2=C(F)C=C(OCCCNC)C=C2F)C(Cl)=NC3=NC=NN13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cevipabulin (TTI-237) 是一种微管活性的、口服有效的抗肿瘤化合物，可抑制 [3H] 长春碱与微管蛋白的结合，对人癌细胞的IC50值为 18-40 nM。 |
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Beyer, C.F., Zhang, N., Hernandez, R., et al.TTI-237: A novel microtubule-active compound with in vivo antitumor activityCancer Res.68(7),2292-2300(2008)
Beyer, C.F., Zhang, N., Hernandez, R., et al.The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like propertiesCancer Chemother. Pharmacol.64(4),681-689(2009)
