Plinabulin
Cat. No.：YN290303
CAS No. ：714272-27-2
| 产品名称: | Plinabulin |
| CAS No.: | 714272-27-2 |
| Chemical Name: | 3Z-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6Z-(phenylmethylene)-2,5-piperazinedione |
| Synonyms: | 普那布林; NPI-2358 |
| 分子量: | 336.39 |
| 分子式: | C₁₉H₂₀N₄O₂ |
| SMILES: | O=C(N/C1=C\C2=C(NC=N2)C(C)(C)C)/C(NC1=O)=C/C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Plinabulin (NPI-2358) 是一种抗微管蛋白解聚的血管破坏剂，能结合 β-微管蛋白 (β-tubulin) 的秋水仙碱结合位点阻止聚合，并且对人肿瘤细胞系具有抑制作用，对 HT-29 细胞系的IC50值为 9.8 nM。 |
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Nicholson, B., Lloyd, G.K., Miller, B.R., et al.NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agentAnticancer Drugs17(1),25-31(2006)
Singh, A.V., Bandi, M., Raje, N., et al.A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cellsBlood117(21),5692-5700(2011)
