Phomopsin A
Cat. No.：YN290531
CAS No. ：64925-80-0
| 产品名称: | Phomopsin A |
| CAS No.: | 64925-80-0 |
| Chemical Name: | (2E)-(βS)-3-chloro-β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-aspartic acid, cyclic (15→3)-ether |
| Synonyms: | 促微管解聚 A |
| 分子量: | 789.23 |
| 分子式: | C₃₆H₄₅ClN₆O₁₂ |
| SMILES: | O=C([C@H](N1)[C@](C)(OC2=CC([C@H](O)[C@H](NC)C(N[C@@H](C(C)=C)C1=O)=O)=CC(Cl)=C2O)CC)N3[C@@H](C=CC3)C(N/C(C(N/C(C(O)=O)=C/C(O)=O)=O)=C(C)/CC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phomopsin A 是一种从真菌Phomopsis leptostomiformis分离的环状六肽霉菌毒素。Phomopsin A 是放射性标记的长春新碱与微管蛋白结合的非竞争性抑制剂。 |
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Cowley, r., Luckett, D.J., Ash, G.J., et al.Identification of QTLs associated with resistance to Phomopsis pod blight (Diaporthe toxica) in Lupinus albusBreed Sci.64(1),83-89(2014)
Hamel, E.Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin BPharmacol. Therapeut.55(1),31-51(1992)
Cormier, A., Marchand, M., Ravelli, R.B.G., et al.Structural insight into the inhibition of tubulin by vinca domain peptide ligandsEMBO reports9(11),1101-1106(2008)
Li, Y., Kobayashi, H., Hashimoto, Y., et al.Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulinsBiochem. Bioph. Res. Co.187(2),722-729(1992)
Mitra, A., and Sept, D.Localization of the antimitotic peptide and depsipeptide binding site on β-tubulinBiochemistry43(44),13955-13962(2004)
