10-Deacetyltaxol
Cat. No.：YN290514
CAS No. ：78432-77-6
| 产品名称: | 10-Deacetyltaxol |
| CAS No.: | 78432-77-6 |
| Chemical Name: | (αR,βS)-β-(benzoylamino)-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1 |
| Synonyms: | 10-去乙酰紫杉醇; 10-Deacetylpaclitaxel |
| 分子量: | 811.87 |
| 分子式: | C₄₅H₄₉NO₁₃ |
| SMILES: | CC(O[C@]12[C@@]([C@]3([C@@H](O)C[C@@]1([H])OC2)C)([H])[C@@H]([C@]4(C(C)(C([C@@H](O)C3=O)=C(C)[C@@H](OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C4)C)O)OC(C7=CC=CC=C7)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 10-Deacetyltaxol (10-Deacetylpaclitaxel) 是从红豆杉中分离得到的一种紫杉醇衍生物。10-Deacetyltaxol (10-Deacetylpaclitaxel) 能促进微管蛋白的聚合，在体外抑制由冷或钙离子诱导的微管解聚。10-Deacetyltaxol (10-Deacetylpaclitaxel) 对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。 |
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McLaughlin, J.L., Miller, R.W., Powell, R.G., et al.19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: New antitumor taxanes from Taxus wallichianaJ. Nat. Prod.44(3),312-319(1981)
Pyo, S.H., Choi, H.J., and Han, B.H.Large-scale purification of 13-dehydroxybaccatin III and 10-deacetylpaclitaxel, semi-synthetic precursors of paclitaxel, from cell cultures of Taxus chinensisJ. Chromatogr. A.1123(1),15-21(2006)
