7-epi-Taxol
Cat. No.：YN290509
CAS No. ：105454-04-4
| 产品名称: | 7-epi-Taxol |
| CAS No.: | 105454-04-4 |
| Chemical Name: | (αR,βS)-β-(benzoylamino)-α-hydroxy-benzenepropanoic acid, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz |
| Synonyms: | 7-表紫杉醇; 7-epi-Paclitaxel |
| 分子量: | 853.91 |
| 分子式: | C₄₇H₅₁NO₁₄ |
| SMILES: | O[C@@H]1C[C@]2([H])[C@](CO2)(OC(C)=O)[C@]3([H])[C@]1(C)C([C@H](OC(C)=O)C4=C(C)[C@@H](OC([C@@H]([C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)O)=O)C[C@]([C@H]3OC(C7=CC=CC=C7)=O)(O)C4(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7-epi-Taxol 是 taxol 的活性代谢物，在抑制细胞增殖及微管 (microtubule) 解离，诱导微管聚合等方面与 taxol 作用相当。 |
| IC50和靶点: | |
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Royer, I., Alvinerie, P., Armand, J.P., et al.Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometryRapid Commun Mass Spectrom.9(6),495-502(1995)
Ringel, I., and Horwitz, S.B.Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture mediumJ. Pharmacol. Exp. Ther.242(2),692-698(1987)
