BNC105
Cat. No.：YN290383
CAS No. ：945771-74-4
| 产品名称: | BNC105 |
| CAS No.: | 945771-74-4 |
| Chemical Name: | (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-methanone |
| Synonyms: | BNC105;(7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone;BNC-105 |
| 分子量: | 372.37 |
| 分子式: | C₂₀H₂₀O₇ |
| SMILES: | COC1=CC(C(C2=C(C)OC3=C(O)C(OC)=CC=C23)=O)=CC(OC)=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BNC105是一种具有抗增殖和破坏肿瘤血管功能的，微管蛋白聚合抑制剂。 |
| IC50和靶点: | |
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Kremmidiotis, G., Leske, A.F., Lavranos, T.C., et al.BNC105: A novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacyMol. Cancer Ther.9(6),1562-1573(2010)
Flynn, B.L., Gill, G.S., Grobelny, D.W., et al.Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting propertiesJ. Med. Chem.54(17),6014-6027(2011)
