ROCK-IN-2
Cat. No.：YN450021
CAS No. ：867017-68-3
规格
价格(RMB)
库存
| 产品名称: | ROCK-IN-2 |
| CAS No.: | 867017-68-3 |
| Chemical Name: | 6-chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine |
| Synonyms: | Azaindole 1; TC-S 7001 |
| 分子量: | 402.79 |
| 分子式: | C₁₈H₁₃ClF₂N₆O |
| SMILES: | NC1=NC(Cl)=CC(NC2=CC(F)=C(OC3=C4C(NC=C4C)=NC=C3)C(F)=C2)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ROCK-IN-2 (Azaindole 1; TC-S 7001) 是有口服活性，ATP-竞争型的ROCK抑制剂，对ROCK-1和ROCK-2的IC50值分别为 0.6 和 1.1 nM。 |
| IC50和靶点: | [{name:"ROCK-1:0.6 nM (IC50)"},{name: "ROCK-2:1.1 nM (IC50)"},{name: "TRK:252 nM (IC50)"},{name: "FLT3:303 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kast, R., Schirok, H., Figueroa-Pérez, S., et al.Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinaseBr. J. Pharmacol.152(7),1070-1080(2007)
Dahal, B.K., Kosanovic, D., Pamarthi, P.K., et al.Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertensionEur. Respir. J.36(4),808-818(2010)
