SAR407899
Cat. No.：YN450108
CAS No. ：923359-38-0
规格
价格(RMB)
库存
| 产品名称: | SAR407899 |
| CAS No.: | 923359-38-0 |
| Chemical Name: | 6-(4-piperidinyloxy)-1(2H)-isoquinolinone |
| Synonyms: | SAR 407899，SAR-407899 |
| 分子量: | 244.29 |
| 分子式: | C₁₄H₁₆N₂O₂ |
| SMILES: | O=C(NC=C1)C(C1=C2)=CC=C2OC3CCNCC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SAR407899 是一种选择性的，有效的，ATP 竞争性的ROCK抑制剂，对ROCK-2的IC50值为 135 nM，对人和大鼠ROCK-2的Ki值分别为 36 nM 和 41 nM。 |
| IC50和靶点: | [{name:"ROCK-2:102 nM (IC50)"},{name: "ROCK-1:276 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Löhn, M., Plettenburg, O., Ivashchenko, Y., et al.Pharmacological characterization of SAR407899, a novel rho-kinase inhibitorHypertension54(3),676-683(2009)
Guagnini, F., Ferazzini, M., Grasso, M., et al.Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosaJ. Transl. Med.10,59(2012)
Grisk, O., Schlüter, T., Reimer, N., et al.The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteriesJ. Hypertens.30(5),980-989(2012)
