GSK269962A
Cat. No.：YN450103
CAS No. ：850664-21-0
规格
价格(RMB)
库存
| 产品名称: | GSK269962A |
| CAS No.: | 850664-21-0 |
| Chemical Name: | N-[3-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide |
| Synonyms: | GSK 269962 |
| 分子量: | 570.60 |
| 分子式: | C₂₉H₃₀N₈O₅ |
| SMILES: | CCN1C2=CC(OC3=CC=CC(NC(C4=CC=C(OCCN5CCOCC5)C=C4)=O)=C3)=NC=C2N=C1C6=NON=C6N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK269962A (GSK 269962) 是一种有效的ROCK抑制剂，作用于重组人ROCK1和ROCK2，IC50分别为 1.6 和 4 nM。GSK269962A 具有抗炎和血管舒张作用。 |
| IC50和靶点: | [{name:"ROCK1:1.6 nM (IC50)"},{name: "ROCK2:4 nM (IC50)"},{name: "RSK1:132 nM (IC50)"},{name: "MSK1:49 nM (IC50)"},{name: "AKT1:955 nM (IC50)"},{name: "AKT2:1350 nM (IC50)"},{name: "AKT3:1510 nM (IC50)"},{name: "CDK2:3500 nM (IC50)"},{name: "GSK3α:1260 nM (IC50)"}] |
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| Solvent & Solubility: |
Doe, C., Bentley, R., Behm, D.J., et al.Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activitiesJ. Pharmacol. Exp. Ther.320(1),89-98(2007)
