GSK180736A
Cat. No.：YN450128
CAS No. ：817194-38-0
规格
价格(RMB)
库存
| 产品名称: | GSK180736A |
| CAS No.: | 817194-38-0 |
| Chemical Name: | 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide |
| Synonyms: | GSK180736 |
| 分子量: | 365.36 |
| 分子式: | C₁₉H₁₆FN₅O₂ |
| SMILES: | CC(N1)=C(C(NC2=CC=C(NN=C3)C3=C2)=O)C(C4=CC=C(F)C=C4)NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK180736A 是一种有效的 Rho 相关卷曲螺旋激酶 1 (ROCK1)，IC50值为 100 nM，也是一种选择性且ATP-竞争性的 G 蛋白偶联受体激酶 2 (GRK2) 的抑制剂，IC50值为 0.77 μM。 |
| IC50和靶点: | [{name:"ROCK1:100 nM (IC50)"},{name: "GRK2:770 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Goodman, K.B., Cui, H., Dowdell, S.E., et al.Development of dihydropyridone indazole amides as selective Rho-kinase inhibitorsJ. Med. Chem.50(1),6-9(2007)
Waldschmidt, H.V., Homan, K.T., Cruz-Rodríguez, O., et al.Structure-based design, synthesis, and biological evaluation of highly selective and potent G protein-coupled receptor kinase 2 inhibitorsJ. Med. Chem.59(8),3793-3807(2016)
