RKI-1447
Cat. No.：YN450112
CAS No. ：1342278-01-6
规格
价格(RMB)
库存
| 产品名称: | RKI-1447 |
| CAS No.: | 1342278-01-6 |
| Chemical Name: | N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-urea |
| Synonyms: | RKI1447 |
| 分子量: | 326.37 |
| 分子式: | C₁₆H₁₄N₄O₂S |
| SMILES: | O=C(NC1=NC(C2=CC=NC=C2)=CS1)NCC3=CC=CC(O)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RKI-1447是高效的ROCK1和ROCK2的小分子抑制剂，IC50值分别为14.5 nM 和6.2 nM。 |
| IC50和靶点: | [{name:"ROCK2:6.2 nM (IC50)"},{name: "ROCK1:14.5 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Patel, R.A., Forinash, K.D., Pireddu, R., et al.RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and anti-tumor activities in breast cancerCancer Res.72(19),5025-5034(2012)
