Belumosudil
Cat. No.：YN450095
CAS No. ：911417-87-3
规格
价格(RMB)
库存
| 产品名称: | Belumosudil |
| CAS No.: | 911417-87-3 |
| Chemical Name: | 2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide |
| Synonyms: | KD025; SLx-2119 |
| 分子量: | 452.51 |
| 分子式: | C₂₆H₂₄N₆O₂ |
| SMILES: | O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Belumosudil (KD025) 是一种选择性的ROCK2抑制剂，对 ROCK2 和 ROCK1 的IC50值分别为 105 nM 和 24 µM。具有抗纤维化特性。 |
| IC50和靶点: | [{name:"ROCK2:105 nM (IC50)"},{name: "ROCK1:24 μM (IC50)"}] |
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| Solvent & Solubility: |
Boerma, M., Fu, Q., Wang, J., et al.Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatinBlood Coagul. Fibrinolysis19(7),709-718(2008)
Tengesdal, I.W., Kitzenberg, D., Li, S., et al.The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6Eur. J. Immunol.48(10),1679-1686(2018)
Wang, H., Zhang, D., Ge, M., et al.Formononetin inhibits enterovirus 71 replication by regulating COX-2/PGE2 expressionVirol. J.12,35(2015)
Flynn, R., Paz, K., Du, J., et al.Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanismBlood127(17),2144-2154(2016)
