Atazanavir
Cat. No.：YN360612
| 产品名称: | Atazanavir |
| CAS No.: | 198904-31-3 |
| Chemical Name: | 3S,12S-bis(1,1-dimethylethyl)-8S-hydroxy-4,11-dioxo-9S-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioic acid, 1,14-dimethyl ester |
| Synonyms: | 阿扎那韦; BMS-232632 |
| 分子量: | 704.86 |
| 分子式: | C₃₈H₅₂N₆O₇ |
| SMILES: | O=C(OC)N[C@@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[C@H](O)[C@H](CC3=CC=CC=C3)NC([C@H](C(C)(C)C)NC(OC)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Atazanavir (BMS-232632) 是一种高选择性的HIV-1蛋白酶抑制剂，用于艾滋病毒感染的研究。Atazanavir 是CYP3A4的底物和抑制剂，也是P-糖蛋白的抑制剂和诱导剂。 |
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Robinson, B.S., Riccardi, K.A., Gong, Y.F., et al.BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agentsAntimicrob. Agents Chemother.44(8),2093-2099(2000)
Michaud, V., Bar-Magen, T., Turgeon, J., et al.The dual role of pharmacogenetics in HIV treatment: Mutations and polymorphisms regulating antiretroviral drug resistance and dispositionPharmacol. Rev.64(3),803-833(2012)
