Chrysosplenetin
Cat. No.：YN360953
| 产品名称: | Chrysosplenetin |
| CAS No.: | 603-56-5 |
| Chemical Name: | 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one |
| Synonyms: | 猫眼草黄素 |
| 分子量: | 374.34 |
| 分子式: | C₁₉H₁₈O₈ |
| SMILES: | O=C1C(OC)=C(C2=CC=C(O)C(OC)=C2)OC3=CC(OC)=C(OC)C(O)=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chrysosplenetin 是青蒿 (Artemisia annua) 和其他几种中草药中的多甲氧基化黄酮类化合物之一。 Chrysosplenetin 抑制P-gp活性并逆转由青蒿素 (ART) 诱导的上调的 P-gp 和 MDR1 水平。 Chrysosplenetin 显着增强 ART 在大鼠血浆水平和抗疟疾功效，部分因为其对大鼠CYP3A的非竞争性抑制作用。 |
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Liu, K.C., Yang, S.L., Roberts, M.F., et al.Antimalarial activity of Artemisia annua flavonoids from whole plants and cell culturesPlant Cell Rep.11(12),637-640(1992)
Dai, W., Bi, J., Li, F., et al.Antiviral efficacy of flavonoids against enterovirus 71 infection in vitro and in newborn miceViruses11(7),625(2019)
Hong, G., He, X., Shen, Y., et al.Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone lossStem Cell Res. Ther.10(1),277(2019)
