Valspodar
Cat. No.：YN360614
| 产品名称: | Valspodar |
| CAS No.: | 121584-18-7 |
| Chemical Name: | 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A |
| Synonyms: | PSC 833 |
| 分子量: | 1214.62 |
| 分子式: | C₆₃H₁₁₁N₁₁O₁₂ |
| SMILES: | O=C([C@H](C(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](C(C)C)N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)N(C)[C@@H](C([C@H](C)C/C=C/C)=O)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Valspodar (PSC 833) 是一种选择性的 P-糖蛋白抑制剂，已被用作化学增敏剂用于实验性癌症的研究。 |
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Boesch, D., Gavériaux, C., Jachez, B., et al.In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833Cancer Res.51(16),4226-4233(1991)
Shirakawa, K., Takara, K., Tanigawara, Y., et al.Interaction of docetaxel ("Taxotere") with human P-glycoproteinJpn. J. Cancer Res.90(12),1380-1386(1999)
Keller, R.P., Altermatt, H.J., Nooter, K., et al.SDZ PSC 833, a non-immunosuppressive cyclosporine: its potency in overcoming P-glycoprotein-mediated multidrug resistance of murine leukemiaInt. J. Cancer50(4),593-597(1992)
Mukae, T., Fujita, W., and Ueda, H.P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central painJ. Pharmacol. Sci.131(1),64-67(2016)
