Zosuquidar trihydrochloride
Cat. No.：YN360707
CAS No. ：167465-36-3
| 产品名称: | Zosuquidar trihydrochloride |
| CAS No.: | 167465-36-3 |
| Chemical Name: | (αR)-4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol, trihydrochloride |
| Synonyms: | 唑喹达三盐酸盐; RS 33295-198 trihydrochloride; LY-335979 trihydrochloride |
| 分子量: | 636.99 |
| 分子式: | C₃₂H₃₄Cl₃F₂N₃O₂ |
| SMILES: | FC1([C@H]2[C@@H]1C3=C([C@@H](C4=CC=CC=C42)N5CCN(CC5)C[C@H](COC6=C7C=CC=NC7=CC=C6)O)C=CC=C3)F.Cl.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zosuquidar (RS 33295-198) trihydrochloride 是 P-糖蛋白 (P-glycoprotein) 抑制剂，Ki值为 59 nM。 |
| IC50和靶点: | |
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Dantzig, A.H., Shepard, R.L., Cao, J., et al.Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979Cancer Res.56(18),4171-4179(1996)
Dantzig, A.H., Shepard, R.L., Law, K.L., et al.Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activitiesJ. Pharmacol. Exp. Ther.290(2),854-862(1999)
Choo, E.F., Leake, B., Wandel, C., et al.Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testesDrug Metab. Dispos.28(6),655-660(2000)
Liu, F., Wang, X., Li, Z., et al.P-Glycoprotein (ABCB1) limits the brain distribution of YQA-14, a novel dopamine D3 receptor antagonistChem. Pharm. Bull. (Tokyo)63(7),512-518(2015)
