Piperine
Cat. No.：YN360911
| 产品名称: | Piperine |
| CAS No.: | 94-62-2 |
| Chemical Name: | (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-2,4-pentadien-1-one |
| Synonyms: | 胡椒碱; Bioperine; 1-Piperoylpiperidine |
| 分子量: | 285.34 |
| 分子式: | C₁₇H₁₉NO₃ |
| SMILES: | O=C(N1CCCCC1)/C=C/C=C/C2=CC=C(OCO3)C3=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Piperine是从胡椒中分离的天然生物碱，可以抑制P-glycoproteinandCYP3A4的活性，在HeLa细胞中的IC50值为61.94±0.054 μg/mL。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
McNamara, F.N., Randall, A., and Gunthorpe, M.J.Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)Br. J. Pharmacol.144(6),781-790(2005)
Schöffmann, A., Wimmer, L., Goldman, D., et al.Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivativesJ. Med. Chem.57(37),5602-5619(2014)
Lee, S.A., Hong, S.S., Han, X.H., et al.Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activityChem. Pharm. Bull. (Tokyo)53(7),832-835(2005)
Murray, M.Toxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insectsJ. Toxicol. Environ. Health B Crit. Rev.15(6),365-395(2012)
Najar, I.A., Sachin, B.S., Sharma, S.C., et al.Modulation of P-glycoprotein ATPase activity by some phytoconstituentsPhytother. Res.24(3),454-458(2010)
