Rosiglitazone
Cat. No.：YN360615
| 产品名称: | Rosiglitazone |
| CAS No.: | 122320-73-4 |
| Chemical Name: | 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | 罗格列酮; BRL 49653 |
| 分子量: | 357.43 |
| 分子式: | C₁₈H₁₉N₃O₃S |
| SMILES: | O=C(N1)SC(CC2=CC=C(OCCN(C)C3=NC=CC=C3)C=C2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rosiglitazone (BRL 49653)，是噻唑烷二酮类胰岛素增敏剂，也是选择性的，具有口服活性PPARγ激动剂，对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。Rosiglitazone 与 PPARγ 结合，Kd约为 40 nM。Rosiglitazone 也是TRPC5的激活剂 (EC50=∼30 μM) 和TRPM3的抑制剂。 |
| IC50和靶点: | [{name:"PPARγ:40 nM (Kd)"},{name: "PPARγ:60 nM (EC50)"},{name: "TRPC5:30 μM (EC50)'}, 'TRPM3'] |
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Kim, J.-H., Lewin, T.M., and Coleman, R.A.Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinedionesJ. Biol. Chem.276(27),24667-24673(2001)
Doll, S., Proneth, B., Tyurina, Y.Y., et al.ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid compositionNat. Chem. Biol.13(1),91-98(2017)
Zhou, J.Y., Zhou, S.W., Zhang, K.B., et al.Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic ratsBiol. Pharm. Bull.31(6),1169-1176(2008)
