PF-4840154
Cat. No.：YN360662
| 产品名称: | PF-4840154 |
| CAS No.: | 1332708-14-1 |
| Chemical Name: | 4-[(2-methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide |
| Synonyms: | |
| 分子量: | 466.62 |
| 分子式: | C₂₆H₃₈N₆O₂ |
| SMILES: | O=C(C1=CN=C(N2CCN(CC3COCCC3)CC2)N=C1NCC(C)C)NCC4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-4840154 是有效，选择性的大鼠和人TrpA1通道激动剂，EC50分别为 97 和 23 nM。PF-4840154 诱导 TrpA1 介导的小鼠伤害行为。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ryckmans, T., Aubdool, A.A., Bodkin, J.V., et al.Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channelBioorg. Med. Chem.21(16),4857-4859(2011)
