8-Gingerol
Cat. No.：YN360928
| 产品名称: | 8-Gingerol |
| CAS No.: | 23513-08-8 |
| Chemical Name: | 5S-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone |
| Synonyms: | |
| 分子量: | 322.44 |
| 分子式: | C₁₉H₃₀O₄ |
| SMILES: | CCCCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-Gingerol 来源于姜的根状茎 (Z. officinale)，具有口服活性，可激活TRPV1，EC50值为5.0 µM。8-Gingerol 抑制COX-2，还能抑制体外H. pylori的生长。 |
| IC50和靶点: | |
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Dedov, V.N., Tran, V.H., Duke, C.C., et al.Gingerols: a novel class of vanilloid receptor (VR1) agonistsBr. J. Pharmacol.137(6),793-798(2002)
Chrubasik, S., Pittler, M.H., and Roufogalis, B.D.Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profilesPhytomedicine12(9),684-701(2005)
Bakht, M.A., Alajmi, M.F., Alam, P., et al.Theoretical and experimental study on lipophilicity and wound healing activity of ginger compoundsAsian Pac. J. Trop. Biomed.4(4),329-333(2014)
Bernard, M., Furlong, S.J., Power Coombs, M.R., et al.Differential inhibition of T lymphocyte proliferation and cytokine synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-GingerolPhytother. Res.29(11),1707-1713(2015)
Townsend, E.A., Zhang, Y., Xu, C., et al.Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteinsAm. J. Respir. Cell Mol. Biol.50(1),115-124(2014)
Mukkavilli, R., Gundala, S.R., Yang, C., et al.Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolicsPLoS One9(9),e108386(2014)
Qiu, J.-X., Zhou, Z.-W., He, Z.-X., et al.Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studiesDrug Des. Devel. Ther.9,841-866(2015)
