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> 产品中心 > 抑制剂 & 激动剂 > Membrane Transporter/Ion Chann > TRP Channel

Dihydrocapsaicin

Cat. No.:YN360923

  • CAS No. :19408-84-5

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Dihydrocapsaicin
      CAS No.: 19408-84-5
      Chemical Name: N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-nonanamide
      Synonyms:二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide,CCRIS1589
      分子量:307.43
      分子式:C₁₈H₂₉NO₃
      SMILES:CC(C)CCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Dihydrocapsaicin 是一种天然辣椒素,为选择性的TRPV1激动剂,同时可以增加 p-Akt 水平。Dihydrocapsaicin 可以增强低温诱导的神经保护。
      IC50和靶点:
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      Clinical Trial:
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    • Nascimento, P.L.A., Nascimento, T.C.E.S., Ramos, N.S.M., et al.Quantification, antioxidant and antimicrobial activity of phenolics isolated from different extracts of Capsicum frutescens (pimenta malagueta)Molecules19(4),5434-5447(2014)

      Choi, C.-H., Jung, Y.-K., and Oh, S.-H.Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell linesFree Radic. Biol. Med.49(2),245-257(2010)

      Wu, D., Shi, J., Elmadhoun, O., et al.Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in ratBrain Res.1671,18-25(2017)

      Feketa, V.V., Balasubramanian, A., Flores, C.M., et al.Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibitionAm. J. Physiol. Regul. Integr. Comp. Physiol.305(9),R1040-R1050(2013)

      Sondo, E., Bertelli, R., Pesce, E., et al.High-content screening identifies vanilloids as a novel class of inhibitors of NET formationFront. Immunol.10,963(2019)

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