Imperatorin
Cat. No.：YN360921
| 产品名称: | Imperatorin |
| CAS No.: | 482-44-0 |
| Chemical Name: | 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one |
| Synonyms: | 欧前胡素; Ammidin |
| 分子量: | 270.28 |
| 分子式: | C₁₆H₁₄O₄ |
| SMILES: | O=C1C=CC2=CC3=C(OC=C3)C(OC/C=C(C)/C)=C2O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Imperatorin 是一种有效的NO synthesis抑制剂，IC50为 9.2 μmol，也是BChE抑制剂，IC50为 31.4 μmol。Imperatorin 是TRPV1的微弱激动剂，EC50为 12.6±3.2 μM。 |
| IC50和靶点: | |
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Li, X., Zeng, X., Sun, J., et al.Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatomaCancer Lett.348(1-2),146-155(2014)
Guo, W., Sun, J., Jiang, L., et al.Imperatorin attenuates LPS-induced inflammation by suppressing NF-κB and MAPKs activation in RAW 264.7 macrophagesInflammation35(6),1764-1772(2012)
Bai, Y., Li, D., Zhou, T., et al.Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activitiesJ. Funct. Foods20,453-462(2016)
