BCTC
Cat. No.：YN360697
| 产品名称: | BCTC |
| CAS No.: | 393514-24-4 |
| Chemical Name: | 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide |
| Synonyms: | N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺 |
| 分子量: | 372.89 |
| 分子式: | C₂₀H₂₅ClN₄O |
| SMILES: | O=C(N1CCN(C2=NC=CC=C2Cl)CC1)NC3=CC=C(C(C)(C)C)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BCTC作用于前列腺癌 (PCa) DU145细胞，有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。 |
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Valenzano, K.J., Grant, E.R., Wu, G., et al.N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1 (2H)-carbox-amide (BCTC), a novel orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic propertiesJ. Pharmacol. Exp. Ther.306(1),377-386(2003)
Gavva, N.R., Tamir, R., Klionsky, L., et al.Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1Mol. Pharmacol.68(6),1524-1533(2005)
