AP-18
Cat. No.：YN361094
CAS No. ：55224-94-7
| 产品名称: | AP-18 |
| CAS No.: | 55224-94-7 |
| Chemical Name: | 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime |
| Synonyms: | |
| 分子量: | 209.67 |
| 分子式: | C₁₁H₁₂ClNO |
| SMILES: | CC(/C(C)=C/C1=CC=C(Cl)C=C1)=N\O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AP-18 是一种选择性TRPA1抑制剂，AP-18 阻断 50 μM 肉桂醛对 TRPA1 的激活，在人和小鼠中的 IC50分别为 3.1 μM 和 4.5 μM。AP-18 逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 以浓度依赖的方式减弱了 30 μM AITC 诱导的 Yo-Pro 摄取，IC50为 10.3 μM。 |
| IC50和靶点: | [{name:"TRPA1:~3 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Chen, J., Kim, D., Bianchi, B.R., et al.Pore dilation occurs in TRPA1 but not in TRPM8 channelsMol. Pain5,3(2009)
Taylor-Clark, T.E., Ghatta, S., Bettner, W., et al.Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1Mol. Pharmacol.75(4),820-829(2009)
