RN-1734
Cat. No.：YN360699
CAS No. ：946387-07-1
| 产品名称: | RN-1734 |
| CAS No.: | 946387-07-1 |
| Chemical Name: | 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-benzenesulfonamide |
| Synonyms: | TRPV4 Antagonist I |
| 分子量: | 353.31 |
| 分子式: | C₁₄H₂₂Cl₂N₂O₂S |
| SMILES: | O=S(C1=CC=C(Cl)C=C1Cl)(N(C(C)C)CCNC(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RN-1734 是一种选择性TRPV4通道拮抗剂，完全拮抗 4αPDD 介导的 TRPV4 活化，作用于 hTRPV4, mTRPV4, 和 rTRPV4，IC50分别为 2.3 μM、5.9 μM、3.2 μM。RN-1734 能明显降低肿瘤坏死因子 α (TNF-α) 和白细胞介素 1β (IL-1β) 的产生，而不改变 olig2- 阳性细胞的数量。 |
| IC50和靶点: | |
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Vincent, F., Acevedo, A., Nguyen, M.T., et al.Identification and characterization of novel TRPV4 modulatorsBiochem. Biophys. Res. Commun.389(3),490-494(2009)
Qi, M., Wu, C., Wang, Z., et al.Transient receptor potential vanilloid 4 activation-induced increase in glycine-activated current in mouse hippocampal pyramidal neuronsCell Physiol. Biochem.45(3),1084-1096(2018)
Bagher, P., Beleznai, T., Kansui, Y., et al.Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar toneProc. Natl. Acad. Sci. USA109(44),18174-18179(2012)
Lu, K.-T., Huang, T.-C., Tsai, Y.-H., et al.Transient receptor potential vanilloid type 4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injuryJ. Neurochem.140(5),718-727(2017)
Arredondo Zamarripa, D., Noguez Imm, R., Bautista Cortés, A.M., et al.Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: Diabetic milieu makes a differenceSci. Rep.7(1):13094,(2017)
