Lu AF21934
Cat. No.：YN320035
CAS No. ：1445605-23-1
| 产品名称: | Lu AF21934 |
| CAS No.: | 1445605-23-1 |
| Chemical Name: | N1-(3,4-dichlorophenyl)-1S,2R-cyclohexanedicarboxamide |
| Synonyms: | Lu AF21934;Lu-AF 21934;(1S,2R)-N1-(3,4-dichlorophenyl)cyclohexane-1,2-dicarboxamide;AM80972;(1R,2S)-2-N-(3,4-dichlorophenyl)cyclohexane-1,2-dicarboxamide |
| 分子量: | 315.20 |
| 分子式: | C₁₄H₁₆Cl₂N₂O₂ |
| SMILES: | O=C([C@@H]1[C@H](C(N)=O)CCCC1)NC2=CC=C(Cl)C(Cl)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lu AF21934 是选择性和脑渗透性的mGlu4受体正变构调节剂，对 mGlu4 受体的EC50为 500。 |
| IC50和靶点: | [{name:"mGlu4 Receptor:500 nM (EC50)"}] |
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Sławińska, A., Wierońska, J.M., Stachowicz, K., et al.Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu4 receptorNeuropharmacology66,225-235(2013)
Sławińska, A., Wierońska, J.M., Stachowicz, K., et al.The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodentsBr. J. Pharmacol.169(8),1824-1839(2013)
Ossowska, K., Wardas, J., Berghauzen-Maciejewska, K., et al.Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in ratsNeuropharmacology83,28-35(2014)
