3,3'-Difluorobenzaldazine
Cat. No.：YN320898
| 产品名称: | 3,3'-Difluorobenzaldazine |
| CAS No.: | 15332-10-2 |
| Chemical Name: | 2-[(3-fluorophenyl)methylene]hydrazone, 3-fluoro-benzaldehyde |
| Synonyms: | DFB |
| 分子量: | 244.24 |
| 分子式: | C₁₄H₁₀F₂N₂ |
| SMILES: | FC1=CC(/C=N/N=C/C2=CC=CC(F)=C2)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3,3'-Difluorobenzaldazine (DFB) 是一种选择性 mGluR5 正变构调节剂。3,3'-Difluorobenzaldazine 可增强 mGlu5 激动剂 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用，EC50在 2 到 5 μM 范围内。 |
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O'Brien, J.A., Lemaire, W., Chen, T.-B., et al.A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5Mol. Pharmacol.64(3),731-740(2003)
Balschun, D., Zuschratter, W., and Wetzel, W.Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memoryNeuroscience142(3),691-702(2006)
