Biphenylindanone A
Cat. No.：YN320987
| 产品名称: | Biphenylindanone A |
| CAS No.: | 866823-73-6 |
| Chemical Name: | 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid |
| Synonyms: | BINA |
| 分子量: | 454.56 |
| 分子式: | C₃₀H₃₀O₄ |
| SMILES: | O=C(C1=CC=C(C2=CC=CC(COC3=CC4=C(C(C(C5CCCC5)C4)=O)C(C)=C3C)=C2)C=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Biphenylindanone A (BINA) 是一种选择性人类代谢型谷氨酸受体 (hmGluR2) 增强剂，可用于研究许多神经系统疾病。 |
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Galici, R., Jones, C.K., Hemstapat, K., et al.Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in miceJ. Pharmacol. Exp. Ther.318(1),173-185(2006)
Dhanya, R.P., Sidique, S., Sheffler, D.J., et al.Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in ratsJ. Med. Chem.54(1),342-353(2011)
Benneyworth, M.A., Xiang, Z., Smith, R.L., et al.A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosisMol. Pharmacol.72(2),477-484(2007)
Hackler, E.A., Byun, N.E., Jones, C.K., et al.Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activationNeuroscience168,209-218(2010)
Jin, X., Semenova, S., Yang, L., et al.The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in ratsNeuropsychopharmacology35(10),2021-2036(2010)
