JNJ-46778212
Cat. No.：YN321230
CAS No. ：1363281-27-9
| 产品名称: | JNJ-46778212 |
| CAS No.: | 1363281-27-9 |
| Chemical Name: | [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-methanone |
| Synonyms: | VU 0409551 |
| 分子量: | 352.36 |
| 分子式: | C₂₀H₁₇FN₂O₃ |
| SMILES: | O=C(N1CCC2=C(OC(COC3=CC=CC=C3)=N2)C1)C4=CC=C(F)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-46778212 (VU 0409551) 是mGlu5正变构调节剂，EC50值为260 nM。 |
| IC50和靶点: | [{name:"mGlu5 Receptor:260 nM (EC50)"}] |
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| Solvent & Solubility: |
Conde-Ceide, S., Martínez-Viturro, C.M., Alcázar, J., et al.Discovery of VU0409551/JNJ-46778212: An mGlu5 positive allosteric modulator clinical candidate targeting schizophreniaACS Med. Chem. Lett.6(6),716-720(2015)
Doria, J.G., de Souza, J.M., Silva, F.R., et al.The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington's diseaseJ. Neurochem.147(2),222-239(2018)
