Eglumegad
Cat. No.：YN321199
| 产品名称: | Eglumegad |
| CAS No.: | 176199-48-7 |
| Chemical Name: | (1S,2S,5R,6S)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
| Synonyms: | LY354740; Eglumetad |
| 分子量: | 185.18 |
| 分子式: | C₈H₁₁NO₄ |
| SMILES: | OC([C@]1([C@]2([H])[C@@H](C(O)=O)[C@]2([H])CC1)N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Eglumegad (LY354740) 是一种有效，选择性的group II (mGlu2/3) receptor激动剂，对人mGlu2和mGlu3受体的IC50分别为5和24 nM。 |
| IC50和靶点: | [{name:"mGluR2R:5 nM (IC50)"},{name: "mGluR3R:24 nM (IC50)"}] |
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Rorick-Kehn, L.M., Johnson, B.G., Burkey, J.L., et al.Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039)J. Pharmacol. Exp. Ther.321(1),308-317(2007)
Schoepp, D.D., Johnson, B.G., Wright, R.A., et al.LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptorsNeuropharmacology36(1),1-11(1997)
Monn, J.A., Valli, M.J., Massey, S.M., et al.Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptorsJ. Med. Chem.42(6),1027-1040(1999)
Marek, G.J., Wright, R.A., Schoepp, D.D., et al.Physiological antagonism between 5-hydroxytryptamine2A and group II metabotropic glutamate receptors in prefrontal cortexJ. Pharmacol. Exp. Ther.292(1),76-87(2000)
Copeland, C.S., Neale, S.A., and Salt, T.E.Actions of xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamusNeuropharmacology66,133-142(2013)
Moghaddam, B., and Adams, B.W.Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in ratsScience281(5381),1349-1352(1998)
Schoepp, D.D., Jane, D.E., and Monn, J.A.Pharmacological agents acting at subtypes of metabotropic glutamate receptorsNeuropharmacology38(10),1431-1476(1999)
