LY341495
Cat. No.：YN321300
CAS No. ：201943-63-7
| 产品名称: | LY341495 |
| CAS No.: | 201943-63-7 |
| Chemical Name: | αS-amino-α-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid |
| Synonyms: | LY 341495; LY-341495 |
| 分子量: | 353.37 |
| 分子式: | C₂₀H₁₉NO₅ |
| SMILES: | O=C(O)[C@@H]1[C@H](C1)[C@@](N)(CC2C3=C(C=CC=C3)OC4=C2C=CC=C4)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY341495 是代谢型谷氨酸受体 (mGluR) 拮抗剂，对 mGlu2，mGlu3，mGlu1a，mGlu5a，mGlu8，mGlu7 和 mGlu4 受体的IC50分别为 21 nM，14 nM，7.8 μM，8.2 μM，170 nM，990 nM 和 22 μM。 |
| IC50和靶点: | [{name:"mGluR1a:7.8 μM (IC50)"},{name: "mGluR2:21 nM (IC50)"},{name: "mGluR3:14 nM (IC50)"},{name: "mGluR4:22 μM (IC50)"},{name: "mGluR5a:8.2 μM (IC50)"},{name: "mGluR7:990 nM (IC50)"},{name: "mGluR8:170 nM (IC50)"}] |
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| Solvent & Solubility: |
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Kingston, A.E., Ornstein, P.L., Wright, R.A., et al.LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptorsNeuropharmacology37(1),1-12(1998)
Bräuner-Osborne, H., Egebjerg, J., Nielsen, E.O., et al.Ligands for glutamate receptors: Design and therapeutic prospectsJ. Med. Chem.43(14),2609-2645(2000)
Wright, R.A., Arnold, M.B., Wheeler, W.J., et al.[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brainJ. Pharmacol. Exp. Ther.298(2),453-460(2001)
Battaglia, G., Busceti, C.L., Pontarelli, F., et al.Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in miceNeuropharmacology45(2),155-166(2003)
Fitzjohn, S.M., Bortolotto, Z.A., Palmer, M.J., et al.The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticityNeuropharmacology37(12),144-1458(1998)
Benneyworth, M.A., Xiang, Z., Smith, R.L., et al.A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosisMol. Pharmacol.72(2),477-484(2007)
Galici, R., Jones, C.K., Hemstapat, K., et al.Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in miceJ. Pharmacol. Exp. Ther.318(1),173-185(2006)
