Basimglurant
Cat. No.：YN320990
| 产品名称: | Basimglurant |
| CAS No.: | 802906-73-6 |
| Chemical Name: | 2-chloro-4-[2-[1-(4-fluorophenyl)-2,5-dimethyl-1H -imidazol-4-yl]ethynyl]-pyridine |
| Synonyms: | RG7090; CTEP Derivative |
| 分子量: | 325.77 |
| 分子式: | C₁₈H₁₃ClFN₃ |
| SMILES: | CC1=C(C#CC2=CC(Cl)=NC=C2)N=C(C)N1C3=CC=C(F)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Basimglurant (RG7090) 是高效，选择性有口服活性的mGlu5负变构调节剂，Kd值为1.1 nM。 |
| IC50和靶点: | [{name:"mGlu5 Receptor:1.1 nM (Kd)"}] |
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Lindemann, L., Porter, R.H., Scharf, S.H., et al.Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depressionJ. Pharmacol. Exp. Ther.353(1),213-233(2015)
