JNJ-42153605
Cat. No.：YN321178
CAS No. ：1254977-87-1
| 产品名称: | JNJ-42153605 |
| CAS No.: | 1254977-87-1 |
| Chemical Name: | 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine |
| Synonyms: | JNJ-42153605,JNJ42153605 |
| 分子量: | 400.44 |
| 分子式: | C₂₂H₂₃F₃N₄ |
| SMILES: | FC(C1=C(N2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-42153605是代谢型谷氨酸2 (mGlu2) 受体的正变构调节剂，EC50值为17 nM。 |
| IC50和靶点: | [{name:"mGluR2:17 nM (EC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Cid, J.M., Tresadern, G., Vega, J.A., et al.Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A positive allosteric modulator of the metabotropic glutamate 2 receptorJ. Med. Chem.55(20),8770-8789(2012)
