Ro 67-7476
Cat. No.：YN320041
CAS No. ：298690-60-5
| 产品名称: | Ro 67-7476 |
| CAS No.: | 298690-60-5 |
| Chemical Name: | 2S-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine |
| Synonyms: | Ro67-7476; Ro-67-7476; Ro 67-7476. |
| 分子量: | 319.39 |
| 分子式: | C₁₇H₁₈FNO₂S |
| SMILES: | O=S(N1[C@H](C2=CC=C(F)C=C2)CCC1)(C3=CC=C(C)C=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 67-7476 是mGluR1的一种有效的正变位调节剂，能增强表达 rat mGluR1a 的 HEK293 细胞中谷氨酸诱导的钙释放，EC50为 60.1 nM。Ro 67-7476 是一种有效的 P-ERK1/2 激动剂，可以在外源添加谷氨酸的情况下激活 ERK1/2 磷酸化 (EC50=163.3 nM)。 |
| IC50和靶点: | [{name:"mGluR1a:60.1 nM (EC50)"}] |
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Knoflach, F., Mutel, V., Jolidon, S., et al.Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding siteProc. Natl. Acad. Sci. USA98(23),13402-13407(2001)
Sheffler, D.J., and Conn, P.J.Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cellsNeuropharmacology55(4),419-427(2008)
