JNJ16259685
Cat. No.:YN320044
CAS No. :409345-29-5
产品名称: | JNJ16259685 |
CAS No.: | 409345-29-5 |
Chemical Name: | (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone |
Synonyms: | .TN.T 16259685 |
分子量: | 325.40 |
分子式: | C₂₀H₂₃NO₃ |
SMILES: | O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)[C@H]4CC[C@@H](OC)CC4 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | JNJ16259685 是一种选择性的mGlu1 receptor拮抗剂,能够浓度依赖性地抑制 mGlu1 的突触的活化,IC50值为 19 nM。 |
IC50和靶点: | [{name:"mGluR1:19 nM (IC50)"}] |
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Lavreysen, H., Wouters, R., Bischoff, F., et al.JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonistNeuropharmacology47(7),961-972(2004)
Steckler, T., Lavreysen, H., Oliveira, A.M., et al.Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression testPsychopharmacology (Berl.)179(1),198-206(2005)